Therapeutic efficacy of Poly(DL-lactide-Co-Glycolide)-encapsulated antitubercular drugs against Mycobacterium tuberculosis infection induced in mice.
نویسندگان
چکیده
Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H(37)Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.
منابع مشابه
Therapeutic implications of nanoencapsulated M. avium / HIV drugs against experimental tuberculosis in mice
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 45 1 شماره
صفحات -
تاریخ انتشار 2001